3-Chloro-5-methoxyaniline

Product Description

3-Chloro-5-methoxyaniline (CAS: 10272-06-7) is an organic building block used in the synthesis of pharmaceutical and agrochemical components. It can be used as an electrophilic partner in a variety of palladium-catalysed cross-coupling reactions and as a nucleophilic reagent in amide couplings. It has been used in the synthesis of ALK2 kinase inhibitors for the treatment of cancer,[1] and in the synthesis of small molecule KRAS G12C inhibitors.[2]

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1) https://worldwide.espacenet.com/patent/search/family/064659499/publication/US11661426B2?q=pn%3DUS11661426

2) https://worldwide.espacenet.com/patent/search/family/083847491/publication/WO2022232320A1?q=pn%3DWO2022232320