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PRODUCT FOCUS - TRIFLUOROMETHANESULPHONIC ACID AND DERIVATIVES
Trifluoromethanesulphonic acid (CF3SO3H) also known as triflic acid is an important reagent and catalyst in modern synthetic chemistry. Interesting applications of triflic acid, triflic anhydride and simple salts or esters have been reviewed in literature to highlight the importance of this family of reagents in the development of novel fine chemicals and pharmaceutical synthesis [1,2].

Methods for introducing the CF3 moiety into molecules are of considerable synthetic and commercial importance. The strong electron-withdrawing properties of the CF3- and –SO2- groups suggest that CF3SO2- anion, known as triflate group is an excellent leaving group used in certain organic reactions such as nucleophilic substitution, Suzuki couplings and Heck reactions [3].

Preparative methods have evolved that utilize substituted aryl compounds as organic electrophiles for C-C bond formation via cross coupling promoted by group 10 transition metals [4]. Since alkyl triflates are extremely reactive in SN2 reactions, they must be stored in conditions free of nucleophiles, i.e. water. The anion owes its stability to resonance stabilization which causes the negative charge to be spread over the three oxygen atoms and the sulfur atom.

New applications continue to be made to both industrial and academic laboratories, along with already established use of triflates as Lewis acids or as counterion for organometallic complexes. The extensive chemistry of triflates is possible due to their stability compared to more traditional catalysts unstable in water, such as aluminium chloride[5,6].

[1]. A.Senning, Chem Rev., 1965, 65, 385.
[2]. R.D.Howells and J.D. McCown, Chem.Rev., 1977, 77, 69.
[3]. S.L.Taylor and J.C. Martin, J.Org.Chem., 1987, 52(19), 4147.
[4]. G.P. Roth and C.E. Fuller, J.Org.Chem., 1991, 56, 3494.
[5]. G.A.Lawrence, Chem. Rev., 1986, 86, 17.
[6]. P.E.Rakita, Chemistry Today, 2004(March/April), 48.

PC7410
Trifluoromethanesulphonic acid 99%
250g
500g
1Kg
Triflic acid
PC7420
Trifluoromethanesulphonic anhydride 99%
250g
500g
1Kg
Triflic anhydride
PC0512
5-(Trifluoromethyl)dibenzo[b,d]thiophenium trifluoromethanesulphonate 97%
1g
5-(Trifluoromethyl)dibenzo[b,d]thiophenium triflate, S-(Trifluoromethyl)dibenzo[b,d]thiophenium triflate
PC0579
Sodium trifluoromethanesulphinate
5g
25g
100g
Trifluoromethanesulphinic acid, sodium salt
PC10403
N,N-Diethylammonium trifluoromethanesulphonate, 60% aqueous solution
250g
1Kg
PC2102
4-Methoxyphenyl trifluoromethanesulphonate
5g
25g
PC2905
3-Fluoroprop-1-yl trifluoromethanesulphonate 95%
1g
5g
3-Fluoroprop-1-yl triflate
PC2971
4,4,4-Trifluorobutyl trifluoromethanesulphonate 97%
1g
5g
PC3284
Ethyl trifluoromethanesulphonate 98%
5g
25g
Ethyl triflate
PC3383
2,2,3,3-Tetrafluoroprop-1-yl trifluoromethanesulphonate 97%
5g
25g
2,2,3,3-Tetrafluoroprop-1-yl triflate, 2,2,3,3-Tetrafluoropropyl trifluoromethanesulphonate
PC3793
2,2-Difluoroethyl trifluoromethanesulphonate 98%
1g
5g
2,2-Difluoroethyl triflate
PC3808
2H-Perfluoroprop-2-yl trifluoromethanesulphonate 97%
1g
5g
1,1,1,3,3,3-Hexafluoroprop-2-yl trifluoromethanesulphonate, 1,1,1,3,3,3-Hexafluoroprop-2-yl triflate
PC3903
2,2,2-Trifluoroethyl trifluoromethanesulphonate 97%
1g
5g
25g
2,2,2-Trifluoroethyl triflate
PC4495
4-(Trifluoromethyl)phenyl trifluoromethanesulphonate 97%
5g
10g
PC4504
4-Chlorophenyl trifluoromethanesulphonate 97%
1g
5g
25g
4-Chlorophenyl triflate
PC49047
2-Chloroethyl trifluoromethanesulphonate
1g
5g
2-Chloroethyl triflate
PC5037
Bis(tert-butyl)silyl bis(trifluoromethanesulphonate)
5g
25g
Bis(tert-butyl)silyl ditriflate, DTBS ditriflate, DTBSDT
PC5170
Methyl trifluoromethanesulphonate 98%
10g
50g
Methyl triflate
PC57000
2-Bromoethyl trifluoromethanesulphonate
5g
2-Bromoethyl triflate
PC6227
N,N-Bis(trifluoromethylsulphonyl)aniline 98%
5g
25g
N-Phenylbis(trifluoromethanesulphonimide), Phenyl triflimide
PC6324
Potassium trifluoromethanesulphonate 99%
25g
100g
Potassium triflate
PC6374
Morpholin-4-ium trifluoromethanesulphonate
5g
25g
Morpholin-4-ium triflate
PC6572
Sodium trifluoromethanesulphonate 98%
5g
25g
Sodium triflate
PC7096
Scandium(III) trifluoromethanesulphonate 99%
1g
5g
Scandium(III) triflate
PC7987
1H,1H-Heptafluorobutyl trifluoromethanesulphonate 97%
5g
25g
1H,1H-Heptafluorobutyl triflate
PC8034
Zinc(II) trifluoromethanesulphonate 98%
5g
25g
Zinc(II) triflate
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