Presented at ESOC-19, July 2019 by our Head of Research and Production UK, Achim Porzelle.
Nowadays reactions performed on milligram scale are dominating the primary literature including patents. Reactions on scale larger than 5g are rarely reported. Can these milligram procedures be used to make 100g of a compound or more? What factors need to be considered to convert a small scale reaction to a multigram procedure? Here we take a look at some key parameters and the challenges we face on a daily basis making synthetic building blocks. In the end the questions are: Have we forgotten about making larger amounts and are we training the skills to synthesise 100g+ to the new generation of chemists?