Product Focus – Cyclopropyl Derivatives
4th May 2020
The cyclopropyl ring exhibits a number of interesting properties such as copolarity of the three carbon atoms, relatively short C-C and C-H bonds and enhanced π-characteristics of the C-C bonds. These allow the cyclopropyl moiety to bestow a range of beneficial effects on drug molecules which contain it. Some examples of this are: increased metabolic stability, enhanced potency, increased brain permeability and reduced off-target effects.
Other advantages include entropically more favourable binding to the receptor, and conformational restriction of peptides and peptidomimetrics to prevent proteolytic hydrolysis. This range of useful properties has led to the use of cyclopropyl-containing compounds in cardiovascular drugs, antidiabeticcs, autoimmune drugs, drugs for respiratory disorders, CNS active drugs, anti-cancer drugs, anti-virals and antibacterials.
OR40778 4-Bromo-2-cyclopropylaniline
OR40807 3-(Cyclopropyl)thiophene
OR42286 2-Amino-6-cyclopropylpyridine
OR42287 3-Amino-5-cyclopropylpyridine
OR42288 4-Amino-3-cyclopropylpyridine
OR46744 2-Bromo-3-cyclopropylthiophene
OR48097 5-Cyclopropyl-2-thiophenesulfonyl chloride
OR51799 2-Bromo-6-cyclopropylphenol
OR54824 4-Cyclopropylthiophene-2-sulfonyl chloride
OR938340 3-(Cyclopropyl)benzoic acid
OR952526 2-Amino-3-cyclopropylpyridine
PC32944 2-Bromo-4-fluoro-1-cyclopropylbenzene
PC32946 2-Bromo-6-fluoro-1-cyclopropylbenzene
PC49415 3-Cyclopropyl-2-fluoroaniline
PC49416 4-Cyclopropyl-2-fluoroaniline
PC49417 5-Cyclopropyl-2-fluoroaniline
PC49418 2-Cyclopropyl-6-fluoroaniline
PC49419 2-Cyclopropyl-3-fluoroaniline
PC49421 3-Cyclopropyl-5-fluoroaniline
PC49423 2-Cyclopropyl-5-fluoroaniline
Search our store for our full range of Cyclopropanes.
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