4th May 2020
The cyclopropyl ring exhibits a number of interesting properties such as copolarity of the three carbon atoms, relatively short C-C and C-H bonds and enhanced π-characteristics of the C-C bonds. These allow the cyclopropyl moiety to bestow a range of beneficial effects on drug molecules which contain it. Some examples of this are: increased metabolic stability, enhanced potency, increased brain permeability and reduced off-target effects.
Other advantages include entropically more favourable binding to the receptor, and conformational restriction of peptides and peptidomimetrics to prevent proteolytic hydrolysis. This range of useful properties has led to the use of cyclopropyl-containing compounds in cardiovascular drugs, antidiabeticcs, autoimmune drugs, drugs for respiratory disorders, CNS active drugs, anti-cancer drugs, anti-virals and antibacterials.
Search our store for our full range of Cyclopropanes.
Apollo Scientific are a leading manufacturer and supplier of high quality research chemicals, supporting discovery across the global market.
We specialise in the manufacture and supply of aromatic, heterocyclic and aliphatic compounds, fluorochemicals and life sciences reagents, and are dedicated to providing a high level of customer service.
As one of the UK’s most established chemical distributors, we have a global reach.
With more than 25,000 products in stock and over 100,000 products listed on our website, look no further to buy research chemicals, organic building blocks, life sciences reagents, high purity inorganics, deuterated solvents, and spectroscopy consumables.
All of our compounds can be searched by CAS, catalog number, substructure or similarity, and you can check compound availability, current prices and lead time information online.To speak to a member of our expert team about research chemical supply, manufacture or distribution email email@example.com or call +44 (0)161 406 0505.