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PRODUCT FOCUS - Phenylpiperidines
Phenylpiperidines, comprising a phenyl moiety directly attached to a piperidine ring, play an important role in diverse medical fields such as anaesthesia and pain medication1. They form an important subset of drugs known as opioid analgesics, which work by binding to specific receptors on neuronal cell membranes.

Depending on the position of attachment of the phenyl group to the piperidine ring, plus any other substituents involved, these compounds exhibit different pharmacological behaviour such as analgesic activity or effects on the central nervous system.

Derivatives of 4-phenyl piperidines have been shown to be high-affinity ligands, which bind selectively at sigma receptors and have reduced affinity for phencyclidine and dopamine receptors2. This behaviour has potential applications in the development of novel psychotherapeutic agents.

Phenylpiperidines have also been used as the scaffold in antidepressants which selectively inhibit the reuptake of serotonin (SSRI class).

A wide variety of phenylpiperidines are available from stock at Apollo, with some examples highlighted below, and we can also offer many related items on a custom synthesis basis from our UK labs.

1 - Pain Phys., 2017(20), SE23-SE31
2 - J. Med. Chem., 34(12), 3360-5

OR321200
(R)-2-Phenylpiperidine
250mg £103.00
1g £257.00
OR321201
(S)-2-Phenylpiperidine
1g £318.00
OR321211
(R)-2-Methyl-2-phenylpiperidine
100mg £185.00
500mg £375.00
OR321218
4-(3-Chloro-5-methoxyphenyl)piperidine hydrochloride
100mg £200.00
OR321219
4-(3,4,5-Trichlorophenyl)piperidine hydrochloride
100mg £400.00
OR321220
2-(Piperidin-4-yl)benzamide hydrochloride
100mg £160.00
OR321221
4-(4-Chloro-3-methoxyphenyl)piperidine hydrochloride
100mg £400.00
OR321222
Methyl 4-(piperidin-4-yl)benzoate hydrochloride
250mg £73.00
1g £165.00
OR321223
Methyl 2-(piperidin-4-yl)benzoate hydrochloride
100mg £200.00
OR321229
(2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride
100mg £200.00
OR321231
4-(3-Chloro-4-(methylsulfonyl)phenyl)piperidine hydrochloride
100mg £150.00
OR321234
(3-(Piperidin-4-yl)phenyl)methanamine dihydrochloride
100mg £200.00
OR321235
(3-(Piperidin-4-yl)phenyl)methanol hydrochloride
100mg £200.00
OR321241
2-(4-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride
100mg £200.00
OR321242
N,N-Dimethyl-1-(3-(piperidin-4-yl)phenyl)methanamine dihydrochloride
100mg £400.00
OR321243
4-(Piperidin-4-yl)phenol hydrochloride
250mg £60.00
1g £150.00
OR321244
N-Methyl-1-(4-(piperidin-4-yl)phenyl)methanamine dihydrochloride
100mg £400.00
OR321245
4-(2-Ethylphenyl)piperidine hydrochloride
100mg £200.00
OR321246
N-Methyl-2-(piperidin-4-yl)benzamide hydrochloride
100mg £200.00
OR321250
tert-Butyl 4-(4-((methylamino)methyl)phenyl)piperidine-1-carboxylate
100mg £400.00
OR321251
N-Methyl-1-(3-(piperidin-4-yl)phenyl)methanamine dihydrochloride
100mg £400.00
OR321252
N,N-Dimethyl-1-(4-(piperidin-4-yl)phenyl)methanamine dihydrochloride
100mg £400.00
OR321253
N,N-Dimethyl-1-(2-(piperidin-4-yl)phenyl)methanamine dihydrochloride
100mg £400.00
OR321254
N-Methyl-1-(2-(piperidin-4-yl)phenyl)methanamine dihydrochloride
100mg £400.00
OR321257
N-Methyl-4-(piperidin-4-yl)benzamide hydrochloride
500mg £260.00
OR321259
tert-Butyl 4-(3-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate
100mg £150.00
OR321260
tert-Butyl 4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate
100mg £200.00
OR321261
tert-Butyl 4-(4-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate
100mg £200.00
OR321262
N-Methyl-4-(piperidin-3-yl)benzamide hydrochloride
100mg £400.00
OR321263
2-(Piperidin-4-yl)phenol hydrochloride
250mg £95.00
1g £240.00
OR321264
4-(2-Chloro-5-methoxyphenyl)piperidine hydrochloride
100mg £200.00
OR321266
N-(4-(Piperidin-3-yl)phenyl)acetamide hydrochloride
100mg £200.00
OR321267
Ethyl (S)-4-(piperidin-2-yl)benzoate hydrochloride
100mg £200.00
OR321268
(R)-2-(4-Methoxyphenyl)piperidine hydrochloride
100mg £200.00
OR321269
(S)-2-(4-Methoxyphenyl)piperidine hydrochloride
100mg £200.00
OR321270
Ethyl (R)-3-(piperidin-2-yl)benzoate hydrochloride
100mg £200.00
OR321271
Ethyl (S)-3-(piperidin-2-yl)benzoate hydrochloride
100mg £400.00
OR321273
4-(Piperidin-3-yl)benzamide hydrochloride
100mg £200.00
OR321287
(S)-3-(4-Bromophenyl)piperidine
250mg £120.00
1g £300.00
OR321331
3-(4-Methoxyphenyl)piperidine
1g £230.00
OR321332
4-(4-Bromophenyl)piperidine
5g £114.00
OR321334
4-(2,3-Dichlorophenyl)piperidine hydrochloride
1g £479.00
OR321343
tert-Butyl (S)-3-(4-bromophenyl)piperidine-1-carboxylate
1g £215.00
PC402100
(S)-2-(4-Fluorophenyl)piperidine hydrochloride
100mg £200.00
PC402101
3-(4-Fluorophenyl)piperidine
250mg £95.00
1g £297.00
PC402104
2-Fluoro-4-(piperidin-4-yl)phenol hydrochloride
100mg £150.00
PC402107
(S)-2-(3,5-Difluorophenyl)piperidine hydrochloride
100mg £200.00
PC402112
4-(2-Chloro-5-fluorophenyl)piperidine hydrochloride
250mg £200.00
PC402114
3-(3,5-Difluorophenyl)piperidine
1g £707.00
Terms and conditions apply : Can not be used in conjunction with any other promotional offer or discount. All catalogue prices are subject to change.
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