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PRODUCT FOCUS - DIFLUOROBENZOIC ACIDS
The ability to introduce fluorinated aromatic moieties into structures easily is becoming increasingly important to synthetic chemists as the commercial applications they may possess become more well-known and understood. The presence of fluorine in a compounds structure can have a substantial impact upon its behaviour, including metabolic stability, membrane permeability and lipophilicity1, as such compounds like difluorobenzene derivatives have been subject to intense scrutiny with proven applications in agrochemical and pharmaceutical compounds2, super elastic materials3 and liquid crystals4.

Using difluorobenzoic acids as building blocks can be an ideal method for introducing difluorobenzene functionality into a chemical structure. The reactivity of the benzoic acid group is such that it will react with a wide number of different functional groups and types of starting material to potentially form a huge number of product types, including benzoic esters, amides and lactams as well as heterocyclics like thiadiazoles5.

This combined with the demand for fluorinated compounds make difluorobenzoic acid building blocks an incredibly versatile and potentially useful collection of starting materials.

A wide range of difluorobenzoic acids are available from stock at Apollo, with many others available on request.

1 J. Med. Chem., 2015, 58, 8315-8359
2 Der Pharma Chemica, 2013, 5, 123-130
3 Angew. Chem. Int. Ed., 2015, 54, 4815-4817
4 Journal of Materials Chemistry C, 2015, 3, 3574-3581
5 J. Chem. Res., 2014, 38, 347-350

PC0494
3,5-Difluoro-4-methoxybenzoic acid 99%
4-Carboxy-2,6-difluoroanisole, 3,5-Difluoro-p-anisic acid
1g £20.00
5g £55.00
PC1133
2,6-Difluoro-3-hydroxybenzoic acid
3-Carboxy-2,4-difluorophenol
250mg £30.00
1g £90.00
PC1142
3,5-Difluoro-2-hydroxybenzoic acid
3,5-Difluorosalicylic acid, 2-Carboxy-4,6-difluorophenol
1g £60.00
5g £205.00
PC200493
3-Bromo-2,4-difluorobenzoic acid
250mg £98.00
1g £299.00
PC49326
5-Bromo-2,4-difluorobenzoic acid 97%
1g £105.00
5g £315.00
PC501567
2-Bromo-4,6-difluorobenzoic acid
1g £160.00
5g £480.00
PC501855
4-Bromo-2,5-difluorobenzoic acid
1g £20.00
5g £65.00
PC501969
5-Bromo-2,3-difluorobenzoic acid
1g £160.00
5g £560.00
PC53246
3-Bromo-4,5-difluorobenzoic acid
1g £36.00
5g £110.00
PC9169
4-Amino-2,3-difluorobenzoic acid
4-Carboxy-2,3-difluoroaniline
1g £93.00
5g £279.00
Terms and conditions apply : Can not be used in conjunction with any other promotional offer or discount. All catalogue prices are subject to change.
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